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Publications

Selected Publications

2017

Hou Y, Kitaguchi T, Kriszt R, Tseng YH, Raghunath. Ca2+-associated triphasic pH changes in mitochondria during brown adipocyte activation. Mol Metab 2017. In press.

Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH. Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight 2017; doi:10.1172/jci.insight.93166. In press.

Lynes M, Leiria L, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH.  The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue.  Nat Med 2017; doi: 10.1038/nm.4297. In press.

Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP, Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sdhaharan T, Ishiwata S, Lane EB, Chang YT, Tseng YH # , Suzuki M # , Raghunath M # . Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes. Sci Rep 2017; 7: 1383 | doi:10.1038/s41598-017- 00291-9. # Corresponding author. In press.

2016

Gao F, McDaniel J, Chen EY, Rockwell H, Lynes MD, Tseng YH, Sarangarajan R, Narain NR and Kiebish MA. Monoacylglycerol analysis using MS/MSALL quadruple time of flight mass spectrometry. Metabolites 2016, 6, 25; doi:10.3390/metabo6030025.

Zhu Y, Gao Y, Tao C, Shao M, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland W, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE. Connexin-43 mediates white adipose tissue beiging by facilitating the propagation of sympathetic neuronal signals. Cell Metab 2016; 24: 420–433.

Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O’Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y., Tseng YH. Loss of BMP receptor type 1A in adipose tissue prevents age-related impairment of glucose homeostasis and insulin sensitivity. Diabetologia 2016; [Epub ahead of print]

Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling. Biochem Biophys Res Commun 2016; 2016; 470(4):783-91 PMID: 26801556

2015

Unsar AM, Mooney B, Hempel N, Corr D, Tseng YH, Xie Y. 3D brown adipogenesis to create “Brown-Fat-in-Microstrands”. Biomaterials 2015; 75:123-134. (PMC journal – in process)

Zhang X, Tian Y, Zhang H, Kavishwar A, Lynes MD, Brownell AL, Sun H, Tseng YH, Moore A, Ran C. Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Sci Rep. 2015; DOI: 10.1038/srep13116. PMC4534785

Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM Tseng YH. Functional and Clonal Analyses of Human Brown and White Fat Progenitors Identify Markers that Predict Thermogenic Capacity of Mature Adipocytes. Nat Med 2015; 21(7):760-768. PMCID: PMC4496292 

Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015; 21(4):389-94. PMCID:PMC4427356   PDF   

Lynes MD, Schulz TJ, Pan AJ, Tseng YH. Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat, but normal muscle development. Endocrinology 2015; epub ahead of print.  PMCID: PMC4398768 

Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH, Goodyear LJ. A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis. Diabetes 2015; epub ahead of print. PMCID: PMC4439563 

2014

Lau AM, Tseng YH, Schulz TJ. Adipogenic fate commitment of muscle-derived progenitor cells: isolation, culture, and differentiation. Methods in Molecular Biology 2014; 1213:229-43. PMID: 25173387

Lynes MD, Tseng YH. Unwiring the transcriptional heat circuit. Proceedings of the National Academy of Sciences 2014; 111(40):14318-9. PMCID: PMC4209983

Huang P, Schulz TJ, Beauvais A, Tseng YH, Gussoni E. Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signaling. Nat Comm 2014; 5;5:4063. PMCID: PMC4084855  PDF

Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell 2014; 158(1):69-83. PMCID: PMC4116691  PDF  

Ussar S, Dankel S, Boucher J, Lee K, Haering MF, Kleinridders A, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med 2014; 6, 247ra103. PMCID: PMC4356008   PDF  

Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle. Stem Cell Reports 2014; 2(1)92-106. PMCID: PMC3966115.  PDF  

Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis. Cell 2014; 156(3):440-55. PMCID: PMC3951122  PDF  

Mwangi SM, Nezami BG, Obukwelu B, Anitha M, Marri S, Fu P, Epperson MF, Le NA, Shanmugam M, Sitaraman SV, Tseng YH, Anania FA, Srinivasan S. Glial cell line-derived neurotrophic factor protects against high fat diet-induced obesity. Am J Physiol Gastrointest Liver Physiol 2014; 306(6):G515-25. PMCID: PMC3949027  PDF  

Townsend KT, Tseng YH. Brown fat fuel utilization and thermogenesis. Trends Endocrinol Metab 2014; 25(4):168-177. PMCID: PMC3972344 (** This article was selected as the 10 best article published in TEM in 2014)  PDF  

2013

Cypess AM, Doyle AN, Sass CA, Huang TL, Mowschenson PM, Rosen HN, Tseng YH, Palmer EL III, Kolodny GM. Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT. J Nuc Med 2013; 19(5):635-9. PMCID: PMC4012367  PDF 

Schulz TJ, Tseng YH. Systemic control of brown fat thermogenesis: integration of peripheral and central signals. Ann. N.Y. Acad. Sci 2013; 1302(1):35-41. PMCID: PMC3805713  PDF  

Townsend KL, An D, Lynes MD, Huang TL, Zhang, H, Goodyear LJ, Tseng YH. Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antiox Redox Signal 2013; 19(3):243-257. PMCID: PMC3691916  PDF  

Schulz TJ, Tseng YH. Brown adipose tissue: development, metabolism and beyond. Biochem J 2013; 453(2):167-78. PMCID: PMC3887508  PDF  

Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 2013; 19(5):635-9. PMCID: PMC3650129  PDF

Ziogas DC, Gras-Miralles B, Mustafa S, Geiger BM, Najarian RM, Nagel JM, Flier SN, Popov Y, Tseng YH, Kokkotou E. Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis. Am J Physiol Gastrointest Liver Physiol 2013; 304(10):G876-84. PMCID: PMC3652072  PDF 

Schulz TJ, Huang P, Huang TL, Xue R, McDougall LE, Townsend KL, Cypess AM, Mishina Y, Gussoni E, Tseng YH. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature 2013; 495(7441):379-83. PMCID: PMC3623555  PDF

Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med 2013; 19(2):217-26. PMCID: PMC3567215  PDF 

Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner K, Hofmann S, Holland J, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever S, Schroeder T, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. p62 links beta-adrenergic input with mitochondrial function. J Clin Invest 2013; 123(1):469-78. PMCID: PMC3533288  PDF  

Stanford KI, Middelbeek RJW, Townsend K, Nygaard EB, An D, Hitchcox KM, Markan KR, Nakano K, Jung DY, Lee Y, Kim JK, Hirshman MF, Tseng YH, Goodyear LJ. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013; 123(1):215-23. PMCID: PMC3533266  PDF 

2012

Macotela Y, Emanuelli B, Mori M, Gesta S, Schulz TJ, Tseng YH, Kahn CR. Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes 2012; 61(7):1691-9. PMCID: PMC3379665  PDF  

Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, He TC, Kokkotou E, Tseng YH. BMP-7 reverses obesity and regulates appetite through a central mTOR pathway. FASEB J 2012; 26(5):2187-96. PMCID: PMC3336788  PDF  

Fujiwaraa K, Hasegawaa K, Ohkumoa T, Miyoshib H, Tseng YH, Yoshikawa K. Necdin controls proliferation of white adipocyte progenitor cells. PLoS One 2012; 7(1):e30948. PMCID: PMC3264651  PDF  

Townsend KT, Tseng YH. Brown adipose tissue: recent insights into development, metabolic function, and therapeutic potential. Adipocyte 2012; 1(1):13-24. PMCID: PMC3661118  PDF  

2011

Cypess AM, Zhang H, Schulz TJ, Huang TL, Espinoza DO, Kristiansen K, Unterman TG, Tseng YH. Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology 2011; 152(10):3680-9. PMCID: PMC3176640  PDF  

Schleinitz D, Klöting N, Böttcher Y, Wolf S, Dietrich K, Tönjes A, Breitfeld J, Enigk B, Halbritter J, Körner A, Schön MR, Jenkner J,Tseng YH, Lohmann T, Dreßler M, Stumvoll M, Blüher M, Kovacs P. Genetic and Evolutionary Analyses of the Human Bone Morphogenetic Protein Receptor 2 (BMPR2) in the Pathophysiology of Obesity. PLoS One 2011; 6(2):e16155. PMCID: PMC3032727  PDF 

Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, Shadrach J, Cerletti M, McDougall LE, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland JL, Wagers AJ, Tseng YH. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad of Sci U S A 2011; 108(1):143-8. PMCID: PMC3017184  PDF  Cited by 219

2010

Zhang H, Schulz TJ, Espinoza DO, Huang TL, Emanuelli B, Kristiansen K, Tseng YH. Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis. Mol Cell Bio 2010; 30(17):4224-33. PMCID: PMC2937545  PDF  

Tseng YH#, Cypess AM, Kahn CR#. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 2010; 9(6):465-81. #Corresponding author. PMCID: PMC2880836  PDF  

Boucher J, Tseng YH, Kahn CR. Insulin and insulin-like growth factor-1 receptors act as ligand specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem 2010; 285(22):17235-45. PMCID: PMC2878077  PDF 

2009

Schulz TJ, Tseng YH. Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev 2009: 20(5-6):523-31. PMCID: PMC2799934  PDF

Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360(15):1509-17. PMCID: PMC2859951  PDF 

Wang WC, Chen HJ, Tseng YH, Lai YC. Identification of somatic mutations in the von Hippel-Lindau (VHL) gene in a patient with renal carcinoma. J Formos Med Assoc 2009; 108(11):886-93. PMID: 19933033 

Böttcher Y, Unbehauen H, Klöting N, Ruschke K, Körner A, Schleinitz D, Tönjes A, Enigk B, Dietrich K, Koriath M, Scholz GH,Tseng YH, Schön MR, Kiess W, Stumvoll M, Blüher M, Kovacs P. Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes 2009; 58(9): 2119-28. PMCID: PMC2731538  PDF

2008

Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008; 454(7207):1000-4. PMCID: PMC2745972  PDF  

Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E. Substance P as a novel anti-obesity target. Gastroenterology 2008; 134(3):747-55. PMCID: PMC2359157  PDF

Krüger M, Kratchmarova I, Blagoev B, Tseng YH, Kahn CR, Mann M. Dissection of the insulin signaling pathway via quantitative phosphoproteomics and knockout mouse model. Proc Natl Acad Sci U S A 2008; 105(7):2451-6. PMCID: PMC2268157  PDF  

2007

Tseng YH#, He T-C. Bone morphogenetic proteins and adipocyte differentiation. Cell Science Reviews 2007; 3(3):342-60. #Corresponding author

Gesta S**, Tseng YH**, Kahn CR. Developmental origin of fat: tracking obesity to its source. Cell 2007; 131(2):242-56. **Equal authorship. PMID: 17956727

Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Bruning J, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Kahn CR, Chen YE. Rad GTPase deficiency leads to cardiac hypertrophy. Circulation 2007; 116(25):2976-83. PMID: 18056528  PDF

Mouche S, Mkaddem SB, Wang W, Katic M, Tseng YH, Carnesecchi S, Steger K, Foti M, Meier CA, Muzzin P, Kahn CR, Ogier-Denis E, Szanto I. The NADPH oxidase NOX4 is a key mediator of adipocyte differentiation. Biochim Biophysica Acta 2007; 1773(7):1015-27. PMID: 17553579 

2005

Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O’Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/H1F1 beta mediates altered gene expression and pancreatic islet dysfunction in human type 2 diabetes. Cell 2005; 122(3):337-49. PMID: 16096055 

Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AL, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol 2005; 7(6):601-11. PMID: 15895078 

Fu M, Zhang J, Tseng YH, Cui T, Zhu X, Xiao Y, Mou Y, Leon HD, Chang M, Hamamori Y, Kahn CR, Chen YE. Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration. Circulation 2005; 111(8):1071-77. PMID: 15710763

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