Selected Publications
2026
Salej Duran L, Camara H, Chaves N, Kodani S, Monahan-Earley R, Huntington S, Cypess A, Asara J, Tseng YH, James B, Gavrila A. Thermogenic Gene Expression in Human Neck Adipose Tissue in Relation to Circulating and Local Thyroid Hormone Levels. Journal of the Endocrine Society, 2026, Vol. 10, No. 1. doi.org/10.1210/jendso/bvaf178 PDF
2025
Corvera S, Rajan A, Townsend K, Shamsi F, Wu J, J Svensson K, Zeltser L, Collins S, Reis T, Tseng YH, Goodyear L. Advances in Adipose Tissue Biology. Endocr Rev 2025 Sep 11:bnaf032. doi: 10.1210/endrev/bnaf032. PMID: 41071598 PDF
Sahin C, Tseng YH. Adipose Progenitor Cells in Thermogenesis and Metabolic Regulation. Physiology (Bethesda). 2025 Aug 1. doi: 10.1152/physiol.00006.2025. Epub ahead of print. PMID: 40748715. PDF
[Correction] Erratum for “Leiria LO, et al., 12-lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat. Cell Metabolism; 2019; S1550-4131(19)30374-2. PMID: 31353262.” Cell Metabolism 2025 Dec 2;37(12):2470-2475. PMID: 41197629. PDF
Pereira O Jr, Serna JDC, Caldeira da Silva CC, Camara H, Kodani SD, Festuccia WT, Tseng YH, Kowaltowski AJ. Mitochondrial ATP-Sensitive K+ channels (MitoKATP) regulate brown adipocyte differentiation and metabolism. American Journal of Physiology-Cell Physiology. 2025. PDF
Zheng R, Zhang Y, Tsuji T, Gao X, Shamsi F, Wagner A, Yosef N, Cui K, Chen H, Kiebish MA, Aristizabal-Henao JJ, Narain NR, Zhang L, Tseng YH, Chen K. MEBOCOST maps metabolite-mediated intercellular communications using single-cell RNA-seq. Nucleic Acids Res. 2025 Jun 20;53(12):gkaf569. doi: 10.1093/nar/gkaf569. PMID: 40568942; PMCID: PMC12199156. PDF
Loft A, Emont MP, Weinstock A, Divoux A, Ghosh A, Wagner A, Hertzel AV, Maniyadath B, Deplancke B, Liu B, Scheele C, Lumeng C, Ding C, Ma C, Wolfrum C, Strieder-Barboza C, Li C, Truong DD, Bernlohr DA, Stener-Victorin E, Kershaw EE, Yeger-Lotem E, Shamsi F, Hui HX, Camara H, Zhong J, Kalucka J, Ludwig JA, Semon JA, Jalkanen J, Whytock KL, Dumont KD, Sparks LM, Muir LA, Fang L, Massier L, Saraiva LR, Beyer MD, Jeschke MG, Mori MA, Boroni M, Walsh MJ, Patti ME, Lynes MD, Blüher M, Rydén M, Hamda N, Solimini NL, Mejhert N, Gao P, Gupta RK, Murphy R, Pirouzpanah S, Corvera S, Tang S, Das SK, Schmidt SF, Zhang T, Nelson TM, O’Sullivan TE, Efthymiou V, Wang W, Tong Y, Tseng YH, Mandrup S, Rosen ED. Towards a consensus atlas of human and mouse adipose tissue at single-cell resolution. Nat Metab. 2025 May 13. doi: 10.1038/s42255-025-01296-9. Epub ahead of print. PMID: 40360756. PDF
Camara H, Park B, Tseng YH. Feeling the pressure: PIEZO2-positive sensory neurons regulate adipose function. Cell Metab. 2025 April 1. doi.org/10.1016/j.cmet.2025.03.007 PDF
Chang YC, Hsieh ML, Lee HL, Hee SW, Chang CF, Yen HY, Chen YA, Chen YR, Chou YW, Li FA, Ke YY, Chen SY, Hung MS, Hung AF, Huang JY, Chiu CH, Lin SY, Shih SF, Hsu CN, Hwang JJ, Yeh TK, Cheng TR, Liao KC, Laio D, Lin SW, Chen TY, Hu CM, Vogel U, Saar D, Kragelund BB, Tsou LK, Tseng YH, Chuang LM. Identification of PTGR2 inhibitors as a new therapeutic strategy for diabetes and obesity. EMBO Mol Med. 2025 Mar 21. doi: 10.1038/s44321-025-00216-4. Epub ahead of print. PMID: 40119175. PDF
Zangerolamo L, Carvalho M, Solon C, Sidarta-Oliveira D, Soares GM, Marmentini C, Boschero AC, Tseng YH, Velloso LA, Barbosa HCL. Central FGF19 signaling enhances energy homeostasis and adipose tissue thermogenesis through sympathetic activation in obese mice. Am J Physiol Endocrinol Metab. 2025 Mar 10. doi: 10.1152/ajpendo.00488.2024. Epub ahead of print. PMID: 40059865. PDF
Da Silva J, Figueiredo A, Tseng YH, Carvalho E, Leal EC. Bone Morphogenetic Protein 7 Improves Wound Healing in Diabetes by Decreasing Inflammation and Promoting M2 Macrophage Polarization. Int. J. Mol. Sci. 2025, Feb 26, 2036. doi: 10.3390/ijms26052036. PDF
Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Gonzales VS, Tsuji T, Wei S, Blüher M, Tseng YH, He C, Kulkarni RN. Divergent roles of m6A in orchestrating brown and white adipocyte transcriptomes and systemic metabolism. Nat Commun. 2025 Jan 9;16(1):533. doi: 10.1038/s41467-024-55694-w. PMID: 39788955. PDF
Cypess AM, Cannon B, Nedergaard J, Kazak L, Chang DC, Krakoff J, Tseng YH, Schéele C, Boucher J, Petrovic N, Blondin DP, Carpentier AC, Virtanen KA, Kooijman S, Rensen PCN, Cero C, Kajimura S. Emerging debates and resolutions in brown adipose tissue research. Cell Metab. 2024 Dec 4:S1550-4131(24)00448-0. doi: 10.1016/j.cmet.2024.11.002. Epub ahead of print. PMID: 39644896. PDF
2024
Okagawa S, Sakaguchi M, Okubo Y, Takekuma Y, Igata M, Kondo T, Takeda N, Araki K, Brandao BB, Qian WJ, Tseng YH, Kulkarni RN, Kubota N, Kahn CR, Araki E. Hepatic SerpinA1 improves energy and glucose metabolism through regulation of preadipocyte proliferation and UCP1 expression. Nat Commun. 2024 Nov 12;15(1):9585. doi: 10.1038/s41467-024-53835-9. PMID: 39532838; PMCID: PMC11557585. PDF
Mauney EE, Wibowo MC, Tseng YH, Kostic A, Adipose tissue–gut microbiome crosstalk in inflammation and thermogenesis, Trends in Endocrinology & Metabolism, 2024, ISSN 1043-2760, doi.org/10.1016/j.tem.2024.10.004. In Press PDF
Xiao L, De Jesus DF, Ju CW, Wei JB, Hu J, DiStefano-Forti A, Tsuji T, Cero C, Männistö V, Manninen SM, Wei S, Ijaduola O, Blüher M, Cypess AM, Pihlajamäki J, Tseng YH, He C, Kulkarni RN. m6A mRNA methylation in brown fat regulates systemic insulin sensitivity via an inter-organ prostaglandin signaling axis independent of UCP1. Cell Metabolism. 2024 Sept; ISSN 1550-4131, doi.org/10.1016/j.cmet.2024.08.006. PDF
Wang CH, Tsuji T, Wu LH, Yang CY, Huang TL, Sato M, Shamsi F, Tseng YH. Endothelin 3/EDNRB signaling induces thermogenic differentiation of white adipose tissue. Nat Commun. 2024 Aug 22;15(1):7215. doi: 10.1038/s41467-024-51579-0. PMID: 39174539; PMCID: PMC11341701. PDF
Dreyfuss JM, Djordjilović V, Pan H, Bussberg V, MacDonald AM, Narain NR, Kiebish MA, Blüher M, Tseng YH, Lynes MD. ScreenDMT reveals DiHOMEs are replicably inversely associated with BMI and stimulate adipocyte calcium influx. Commun Biol. 2024 Aug 14;7(1):996. doi: 10.1038/s42003-024-06646-z. PMID: 39143411; PMCID: PMC11324735. PDF
Tsuji T, Tolstikov V, Zhang Y, Huang TL, Camara H, Halpin M, Narain NR, Yau KW, Lynes MD, Kiebish MA, Tseng YH. Light-responsive adipose-hypothalamus axis controls metabolic regulation. Nat Commun 15, 6768 (2024). doi: 10.1038/s41467-024-50866-0 PDF
Bolin AP, de Fatima Silva F, Salgueiro RB, Dos Santos BA, Komino ACM, Andreotti S, de Sousa É, de Castro É, Real CC, de Paula Faria D, Souza GP, Camara H, Sorgi CA, Tseng YH, Lima FB, Rodrigues AC. Glucocorticoid modulates oxidative and thermogenic function of rat brown adipose tissue and human brown adipocytes. J Cell Physiol. 2024 Sep;239(9):1-12. doi: 10.1002/jcp.31397. Epub 2024 Aug 1. PMID: 39091018. PDF
Chang YH, Tseng YH, Wang JM, Tsai YS, Huang HS. TG-interacting factor 1 regulates mitotic clonal expansion during adipocyte differentiation. Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Apr 2:159492. doi: 10.1016/j.bbalip.2024.159492. Epub ahead of print. PMID: 38575107.PDF
Melchiorre CK, Lynes MD, Bhandari S, Su SC, Potts CM, Thees AV, Norris CE, Liaw L, Tseng YH, Lynes MA, Extracellular metallothionein as a therapeutic target in the early progression of Type 1 Diabetes, Cell Stress and Chaperones, 2024, ISSN 1355-8145, doi: 10.1016/j.cstres.2024.03.005. PDF
Chang YH, Tseng YH, Wang JM, Tsai YS, Liu XL, Huang HS. Phosphorylation of TG-interacting factor 1 at carboxyl-terminal sites in response to insulin regulates adipocyte differentiation. FEBS Lett. 2024 Mar 12. doi: 10.1002/1873-3468.14849. Epub ahead of print. PMID: 38472156. PDF
Walker ME, Kodani SD, Mena HA, Tseng YH, Cypess AM, Spite M. Brown adipose tissue activation in humans increases plasma levels of lipid mediators. J Clin Endocrinol Metab. 2024 Jan 10:dgae016. doi: 10.1210/clinem/dgae016. Epub ahead of print. PMID: 38198796. PDF
2023
Hu D, Tan M, Lu D, Kleiboeker B, Liu X, Park H, Kravitz A, Shoghi K, Tseng YH, Razani B, Ikeda A, Lodhi I TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis. Nat Commun 14, 6099 (2023). doi: 10.1038/s41467-023-41849-8 PDF
Lynes M, Huang Q, Cora C, Su SC, Yi P, Tseng YH. A CRISPR Screen Identifies the E3 Ubiquitin Ligase Rfwd2 asa Negative Regulator of Glucose Uptake in Brown Adipocytes Genes 2023,14, 1865. doi:10.3390/genes14101865 PDF
Rao J, Djeffal Y, Chal J, Marchianò F, Wang CH, Al Tanoury Z, Gapon S, Mayeuf-Louchart A, Glass I, Sefton E, Habermann B, Kardon G, Watt F, Tseng YH, Pourquié O. Reconstructing human brown fat developmental trajectory in vitro, Developmental Cell, 2023, ISSN 1534-5807, doi: 10.1016/j.devcel.2023.08.001. PDF
Shamsi F, Zheng R, Ho LL, Chen K, Tseng YH. Comprehensive analysis of intercellular communication in the thermogenic adipose niche. Commun Biol. 2023 Jul 21;6(1):761. doi: 10.1038/s42003-023-05140-2. PMID: 37479789 PDF
Martí-Pàmies Í, Thoonen R, Morley M, Graves L, Tamez J, Caplan A, McDaid K, Yao V, Hindle A, Gerszten RE, Farrell LA, Li L, Tseng YH, Profeta G, Buys ES, Bloch DB, Scherrer-Crosbie M. Brown Adipose Tissue and BMP3b Decrease Injury in Cardiac Ischemia-Reperfusion. Circ Res. 2023 Jul 18. doi: 10.1161/CIRCRESAHA.122.322337. Online ahead of print. PMID: 37462036
Tsuji T, Zhang Y, Tseng YH. Generation of Brown Fat-Specific Knockout Mice Using a Combined Cre-LoxP, CRISPR-Cas9, and Adeno-Associated Virus Single-Guide RNA System. J Vis Exp. 2023 Mar 24;(193). doi: 10.3791/65083. PMID: 37036212. PDF
Gupta A, Efthymiou V, Kodani SD, Shamsi F, Patti ME, Tseng YH, Streets A. Mapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seqMol Metab. 2023 Jun 5:101746. doi: 10.1016/j.molmet.2023.101746. Online ahead of print. PMID: 37286033. PDF
Iwasaki K, Lalani B, Kahng J, Carapeto P, Sanjines S, Hela F, Abarca C, Tsuji T, Darcy J, Bartke A, Tseng YH, Kulkarni R, Aguayo-Mazzucato C. Decreased IGF1R Attenuates Senescence and Improves Function in Pancreatic β-Cells. Front. Endocrinol. Volume 14 – 2023 | doi: 10.3389/fendo.2023.1203534.
Tsuji T, Tseng YH. Adipose tissue-derived lipokines in metabolism. Curr Opin Genet Dev. 2023 Jul 18;81:102089. doi: 10.1016/j.gde.2023.102089. Online ahead of print. PMID: 37473635. PDF
2022
Kempf E, Landgraf K, Stein R, Hanschkow M, Hilbert A, Abou Jamra R, Boczki P, Herberth G, Kühnapfel A, Tseng YH, Stäubert C, Schöneberg T, Kühnen P, Rayner NW, Zeggini E, Kiess W, Blüher M, Körner A. Aberrant expression of agouti signaling protein (ASIP) as a cause of monogenic severe childhood obesity. Nat Metab. 2022 Dec 19. doi: 10.1038/s42255-022-00703-9. Epub ahead of print. PMID: 36536132. PDF
Tseng YH. Adipose tissue in communication: within and without. Nat Rev Endocrinol. 2022 Dec 16:1–2. doi: 10.1038/s41574-022-00789-x. Epub ahead of print. PMID: 36526875; PMCID: PMC9756712. PDF
Rahbani JF, Scholtes C, Lagarde DM, Hussain MF, Roesler A, Dykstra CB, Bunk J, Samborska B, O’Brien SL, Tripp E, Pacis A, Angueira AR, Johansen OS, Cinkornpumin J, Hossain I, Lynes MD, Zhang Y, White AP, Pastor WA, Chondronikola M, Sidossis L, Klein S, Kralli A, Cypess AM, Pedersen SB, Jessen N, Tseng YH, Gerhart-Hines Z, Seale P, Calebiro D, Giguère V, Kazak L. ADRA1A-Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP. Nat Metab. 2022 Nov 7. doi: 10.1038/s42255-022-00667-w. Epub ahead of print. PMID: 36344764. PDF
Xiao H, Bozi LHM, Sun Y, Riley CL, Philip VM, Chen M, Li J, Zhang T, Mills EL, Emont MP, Sun W, Reddy A, Garrity R, Long J, Becher T, Vitas LP, Laznik-Bogoslavski D, Ordonez M, Liu X, Chen X, Wang Y, Liu W, Tran N, Liu Y, Zhang Y, Cypess AM, White AP, He Y, Deng R, Schöder H, Paulo JA, Jedrychowski MP, Banks AS, Tseng YH, Cohen P, Tsai LT, Rosen ED, Klein S, Chondronikola M, McAllister FE, Van Bruggen N, Huttlin EL, Spiegelman BM, Churchill GA, Gygi SP, Chouchani ET. Architecture of the outbred brown fat proteome defines regulators of metabolic physiology. Cell. 2022 Nov 2:S0092-8674(22)01318-6. doi: 10.1016/j.cell.2022.10.003. Epub ahead of print. PMID: 36334589. PDF
Sakaguchi M, Okagawa S, Okubo Y, Otsuka Y, Fukuda K, Igata M, Kondo T, Sato Y, Yoshizawa T, Fukuda T, Yamagata K, Cai W, Tseng YH, Sakaguchi N, Kahn CR, Araki E. Phosphatase protector alpha4 (α4) is involved in adipocyte maintenance and mitochondrial homeostasis through regulation of insulin signaling. Nat Commun. 2022 Oct 14;13(1):6092. doi: 10.1038/s41467-022-33842-4. PMID: 36241662; PMCID: PMC9568526. PDF
Park K, Li Q, Lynes MD, Yokomizo H, Maddaloni E, Shinjo T, St-Louis R, Li Q, Katagiri S, Fu J, Clermont A, Park H, Wu IH, Yu MG, Shah H, Tseng YH, King GL. Endothelial Cells Induced Progenitors Into Brown Fat to Reduce Atherosclerosis. Circ Res. 2022 Jul 8;131(2):168-183. doi: 10.1161/CIRCRESAHA.121.319582. Epub 2022 Jun 1. PMID: 35642564; PMCID: PMC9308716. PDF
Sugimoto S, Mena HA, Sansbury BE, Kobayashi S, Tsuji T, Wang CH, Yin X, Huang TL, Kusuyama J, Kodani SD, Darcy J, Profeta G, Pereira N, Tanzi RE, Zhang C, Serwold T, Kokkotou E, Goodyear LJ, Cypess AM, Leiria LO, Spite M, Tseng YH. Brown adipose tissue-derived MaR2 contributes to cold-induced resolution of inflammation. Nat Metab. 2022 Jun;4(6):775-790. doi: 10.1038/s42255-022-00590-0. Epub 2022 Jun 27. PMID: 35760872. PDF
Townsend KL, Pritchard E, Coburn JM, Kwon YM, Blaszkiewicz M, Lynes MD, Kaplan DL, Tseng YH. Silk Hydrogel-Mediated Delivery of Bone Morphogenetic Protein 7 Directly to Subcutaneous White Adipose Tissue Increases Browning and Energy Expenditure. Front Bioeng Biotechnol. 2022 May 12;10:884601. doi: 10.3389/fbioe.2022.884601. PMID: 35646839; PMCID: PMC9135469. PDF
Tsuji T, Bussberg V, MacDonald AM, Narain NR, Kiebish MA, Tseng YH. Transplantation of Brown Adipose Tissue with the Ability of Converting Omega-6 to Omega-3 Polyunsaturated Fatty Acids Counteracts High-Fat-Induced Metabolic Abnormalities in Mice. International Journal of Molecular Sciences. 2022; 23(10):5321. https://doi.org/10.3390/ijms23105321. PDF
Rosina M, Ceci V, Turchi R, Chuan L, Borcherding N, Sciarretta F, Sánchez-Díaz M, Tortolici F, Karlinsey K, Chiurchiù V, Fuoco C, Giwa R, Field RL, Audano M, Arena S, Palma A, Riccio F, Shamsi F, Renzone G, Verri M, Crescenzi A, Rizza S, Faienza F, Filomeni G, Kooijman S, Rufini S, de Vries AAF, Scaloni A, Mitro N, Tseng YH, Hidalgo A, Zhou B, Brestoff JR, Aquilano K, Lettieri-Barbato D. Ejection of damaged mitochondria and their removal by macrophages ensure efficient thermogenesis in brown adipose tissue. Cell Metab. 2022 Mar 15:S1550-4131(22)00088-2. doi: 10.1016/j.cmet.2022.02.016. Epub ahead of print. PMID: 35305295. PDF
Kodani SD, Bussberg V, Narain NR, Kiebish MA, Tseng YH. Signaling Lipidomic Analysis of Thermogenic Adipocytes. Methods Mol Biol. 2022;2448:251-271. doi: 10.1007/978-1-0716-2087-8_16. PMID: 35167102. PDF
Lynes MD, Carlone DL, Townsend KL, Breault DT, Tseng YH. Telomerase reverse transcriptase expression marks a population of rare adipose tissue stem cells. Stem Cells 2022. DOI: https://doi.org/10.1093/stmcls/sxab005. PDF
Gupta A, Shamsi F, Altemose N, Dorlhiac GF, Cypess AM, White AP, Yosef N, Patti ME, Tseng YH, Streets A. Characterization of transcript enrichment and detection bias in single-nucleus RNA-seq for mapping of distinct human adipocyte lineages. Genome Res. 2022 Jan 18. doi: 10.1101/gr.275509.121. Epub ahead of print. PMID: 35042723. PDF
2021
Shamsi F, Wang CH, Tseng YH. The evolving view of thermogenic adipocytes – ontogeny, niche and function. Nat Rev Endocrinol. 2021 Oct 8. doi: 10.1038/s41574-021-00562-6. Epub 2021. PMID: 34625737. PDF
Cero C, Lea HJ, Zhu KY, Shamsi F, Tseng YH, Cypess AM. β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis. JCI Insight 2021 Jun 8;6(11):139160. doi: 10.1172/jci.insight.139160. PMID: 34100382. PDF
Lundh M, Altıntaş A, Tozzi M, Fabre O, Ma T, Shamsi F, Gerhart-Hines Z, Barrès R, Tseng YH, Emanuelli B. Cold-induction of afadin in brown fat supports its thermogenic capacity. Sci Rep. 2021 May 7;11(1):9794. doi: 10.1038/s41598-021-89207-2. PMID: 33963248. PMCID: PMC8105362. PDF
Kodani S, Tseng YH. Narrating the story ARC of adipose tissue aging. Developmental Cell 2021;56(10):1359-1360. DOI: 0.1016/j.devcel.2021.04.020. PMID: 34004148. PDF
Löffler MC, Betz MJ, Blondin DP, Augustin R, Sharma AK, Tseng YH, Scheele C, Zimdahl H, Mark M, Hennige AM, Wolfrum C, Langhans W, Hamilton BS, Neubauer H. Challenges in tackling energy expenditure as obesity therapy – from preclinical models to clinical application. Mol Metab 2021. DOI:10.1016/j.molmet.2021.101237. PDF
Shamsi F, Piper M, Ho L-L, Huang TL, Gupta A, Streets A, Lynes MD, Tseng YH. Vascular smooth muscle-derived TRPV1-positive progenitors are a source of cold-induced thermogenic adipocytes. Nat Metab 2021 Apr 12. DOI: 10.1038/s42255-021-00373-z. Epub ahead of print. PMID: 33846638. PDF
Angueira AR, Sakers AP, Holman CD, Cheng L, Arbocco MN, Shamsi F, Lynes MD, Shrestha R, Okada C, Batmanov K, Susztak K, Tseng YH, Liaw L, Seale P. Defining the lineage of thermogenic perivascular adipose tissue. Nat Metab 2021 Apr 12. DOI: 10.1038/s42255-021-00380-0. Epub ahead of print. PMID: 33846639. PDF
Schlein C, Fischer AW, Sass F, Worthmann A, Tödter K, Jaeckstein MY, Behrens J, Lynes MD, Kiebish MA, Narain NR, Bussberg V, Darkwah A, Jespersen NZ, Nielsen S, Scheele C, Schweizer M, Braren I, Bartelt A, Tseng YH, Heeren J, Scheja L. Endogenous Fatty Acid Synthesis Drives Brown Adipose Tissue Involution. Cell Rep. 2021 Jan 12;34(2):108624. PMID: 33440156. PDF
Farnaz S, Tseng YH, CR Kahn. Adipocyte Microenvironment: Everybody in the Neighborhood Talks about the Temperature. Cell Metab 2021;33(1):1-6. DOI: 10.1016/j.cmet.2020.12.012. PDF
2020
Wolfs D, Lynes MD, Tseng YH, Pierce S, Bussberg V, Darkwah A, Tolstikov V, Narain NR, Rudolph MC, Kiebish MA, Demerath EW, Fields DA, Isganaitis E. Brown fat-activating lipokine 12,13-diHOME in human milk is associated with infant adiposity. J Clin Endocrinol Metab. 2020 Nov 2:dgaa799. DOI: 10.1210/clinem/dgaa799. Online ahead of print. PMID: 33135728. PDF
Blaszkiewicz, M, Wood E, Koizar S, Willows J, Anderson R, Tseng YH, Godwin J, Townsend K. The involvement of neuroimmune cells in adipose innervation. Mol Med. 2020. PDF
Leiria LO, Tseng YH. Lipidomics of brown and white adipose tissue: Implications for energy metabolism. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Oct;1865(10):158788. doi: 10.1016/j.bbalip.2020.158788. Epub 2020 Aug 4. PMID: 32763428; PMCID: PMC7484152. PDF
Wang, CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, Leiria LO, Shamsi F, Darcy J, Greenwood BP, Narain NR, Tolstikov V, Smith KL, Emanuelli B, Chang YT, Hagen S, Danial NN, Kiebish MA, Tseng YH. CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice. Sci Transl Med 2020;12(558):1-14. DOI: 10.1126/scitranslmed.aaz8664. PDF
Darcy, J, Tseng YH. The link between stress and IL-6 is heating up. Cell Metab 2020; 32:152-153. DOI:10.1016/j.cmet.2020.07.011. PDF
Knights A, Wu J, Tseng YH. The heating microenvironment: intercellular crosstalk within thermogenic adipose tissue. Diabetes 2020; 69(8):1599-1604. PMID: 32690661. PDF
Lynes MD, Tseng YH. Commentary on: “The Presence of Active Brown Adipose Tissue Determines Cold-Induced Energy Expenditure and Oxylipin Profiles in Humans.” J Clin Endocrinol Metabo 2020; 105(8):dgaa339. PMCID: PMC7304926. PDF
Darcy J, Fang Y, McFadden S, Leiria LO, Dreyfuss JM, Bussburg V, Tolstikov V, Greenwood B, Narain NR, Kiebish MA, Bartke A, Tseng YH. Integrated metabolomics reveals altered lipid metabolism in adipose tissue in a model of extreme longevity. GeroScience 2020. DOI: 10.1007/s11357-020-00221-0. PDF
Pirouz M, Wang CH, Liu Q, Ebrahimi A, Shamsi F, Tseng YH, and Gregory R. The Perlman syndrome DIS3L2 exoribonuclease safeguards endoplasmic reticulum-targeted mRNA translation and calcium ion homeostasis. Nat Commun 2020;11(1):2619. PMCID: PMC7250864. PDF
Ramirez AK, Dankel SN, Rastegarpanah B, Cai W, Xue R, Crovella M, Tseng, YH, Kahn CR, Kasif S. Single-cell transcriptional networks in differentiating preadipocytes suggest drivers associated with tissue heterogeneity. Nat Commun. 2020;11(1):2117. PMCID: PMC7192917. PDF
De Jesus DF, Orime K, Kaminska D, Kimura T, Basile G, Wang CH, Haertle L, Riemens R, Brown N, Hu J, Männistö V, Silva A, Dirice E, Tseng YH, Haaf T, Pihlajamäki J, Kulkarni RN. Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice. J Clin Invest. 2020;130(5):2391–2407. PMCID: PMC7190992. PDF
Shwartz Y, Gonzalez-Celeiro M, Chen CL, Pasolli HA, Sheu SH, Fan S, Shamsi F, Assaad S, Lin E, Zhang B, Tsai PC, He M, Tseng YH, Lin SJ, and Hsu YC. Cell types promoting goosebumps form a niche to regulate hair follicle stem cells. Cell 2020. DOI: 10.1016/j.cell.2020.06.03. PMCID: PMC7540726. PDF
Darcy J, Wang CH, Tseng YH. Analyzing Mitochondrial Function in Brown Adipocytes with a Bioenergetic Analyzer. Methods Mol Biol. 2020; 2138:289-296. PDF
Sato M, Tsuji T, Yang K, Ren X, Dreyfuss JM, Huang TL, Wang CH, Shamsi F, Leiria LO, Lynes MD, Yau KW, Tseng YH. Cell-autonomous light sensitivity via Opsin3 regulates fuel utilization in brown adipocytes. PLOS Biology, 2020. PMCID: PMC7034924. PDF
Shamsi F, Xue R, Huang TL, Lundh M, Liu Y, Leiria LO, Lynes MD, Kempf E, Wang CH, Sugimoto S, Nigro P, Landgraf K, Schulz T, Li Y, Emanuelli B, Kothakota S, Williams LT, Jessen N, Pedersen SB, Böttcher Y, Blüher B, Körner A, Goodyear LJ, Mohammadi M, Kahn CR, Tseng YH. FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis. Nat Comm 2020 11(1): 1421. PMCID: PMC7078224. PDF
2019
Lynes MD, Kodani SD, Tseng YH. Lipokines and Thermogenesis. Endocrine Society, 2019. DOI: 10.1210/en.2019-00337. PDF
Darcy J, Tseng YH. ComBATing aging-does increased brown adipose tissue activity confer longevity? Geroscience, 2019. PMCID: PMC6702504. PDF
Lundh M, Petersen PSS, Isidor MS, Kazoka-Sørensen DNM, Plucinska K, Shamsi F, Ørskov C, Tozzi M, Brown EL, Andersen E, Ma T, Müller U, Barres R, Kristiansen VG, Gerhart-Hines Z, Tseng YH, Emanuelli B. Afadin is a scaffold protein repressing insulin action via HDAC6 in adipose tissue. EMBO Reports 2019. PMCID: PMC6680131. PDF
Leiria LO, Wang CH, Lynes MD, Yang K, Shamsi F, Sato M, Sugimoto S, Chen EY, Bussberg V, Narain NR, Sansbury BE, Darcy J, Huang TL, Kodani SD, Sakaguchi M, Rocha AL, Schulz TJ, Bartelt A, Hotamisligil GS, Hirshman MF, Leyen KV, Goodyear LJ, Bluher M, Cypess AM, Kiebish MA, Spite M, Tseng YH. 12-lipoxygenase regulates cold adaptation and glucose metabolism by producing the omega-3 lipid 12-HEPE from brown fat. Cell Metabolism; 2019; S1550-4131(19)30374-2. PMID: 31353262. PDF
Takahashi H, Alves CRR, Stanford KI, Middelbeek RJW, Nigro P , Ryan RE, Xue R, Sakaguchi M, Lynes MD, So K, Mul JD, Lee MY , Balan E, Pan H, Dreyfuss JM, Hirshman MF, Azhar M, Hannukainen JC, Nuutila P, Kalliokoski KK, Nielsen S, Pedersen BK, Kahn CR, Tseng YH, Goodyear LJ. TGF-β2 is an exercise-induced adipokine that regulates glucose and fatty acid metabolism. Nat Metab 2019; 1:291-303. PDF
2018
Gupta MK, De Jesus DF, Kahraman S, Valdez IA, Shamsi F , Yi L, Swensen AC, Tseng YH, Qian WJ, Kulkarni RN. Insulin receptor-mediated signaling regulates pluripotency markers and lineage differentiation. Mol Metab 2018. PDF
Arai S, Kriszt R, Harada K, Looi LS, Matsuda S, Wongso D, Suo S, Ishiura S, Tseng YH, Raghunath M, Ito T, Tsuboi T, Kitaguchi T. RGB-color intensiometric indicators visualize spatiotemporal dynamics of ATP in single cells. AngewChemInt Ed Engl 2018; 57(34):10873-10878. PDF
Lynes, M. D., Shamsi, F., Sustarsic, E. G., Leiria, L. O., Wang, C. H., Su, S. C., Huang, T. L., Gao, F., Narain, N. R., Chen, E. Y., Cypess, A. M., Schulz, T. J., Gerhart-Hines, Z., Kiebish, M. A., Tseng, Y. H. (2018). Cold-Activated Lipid Dynamics in Adipose Tissue Highlights a Role for Cardiolipin in Thermogenic Metabolism. Cell Reports, 24(3), 781-790. PMCID: PMC6117118 PDF
Lynes M, Tseng YH . Deciphering adipose tissue heterogeneity. Ann. N.Y. Acad. Sci 2018 PMCID: PMC5788721. PDF
Sustarsic EG, Ma T, Lynes MD, Larsen M, Karavaeva L, Havelund JF, Nielsen CH, Jedrychowski MP, Moreno-Torres M, Lundh M, Plucinska K, Jespersen NZ, Grevengoed TJ, Kramar B, Peics J, Hansen JB, Shamsi F, Forss I, Neess D, Keipert S, Wang J, Stohlmann K, Brandslund I, Christensen C, Jørgensen ME, Linneberg A, Pedersen O, Kiebish MA, Qvortrup K, Han X, Pedersen BK, Jastroch M, Mandrup S, Kjær A, Gygi SP, Hansen T, Gillum MP, Grarup N, Emanuelli B, Nielsen S, Scheele C, Tseng YH, Færgeman NJ, Gerhart-Hines Z. Cardiolipin Synthesis in brown and beige fat mitochondria is essential for systemic energy homeostasis. Cell Metab2018;28(1):159-174.e11. PMCID: PMC6038052. PDF
Stanford K, Lynes M, Takahashi H, Baer LA, Arts PJ, May FJ, Lehnig AC, Middelbeek RJW, Richard JJ, So K, Chen EY, Gao F, Narain NR, Distefano G, Shettigar VK, Hirshman MF, Ziolo MT, Kiebish MA, Tseng YH, Coen PM, Goodyear LJ. 12,13-diHOME: An exercise-induced lipokine that increases skeletal muscle fatty acid uptake. Cell Metab 2018; 1;27(5):1111-1120.e3. PMCID: PMC5935136. PDF
Bartelt A, Widenmaier SB, Schlein C, Johann K, Goncalves RLS, Eguchi K, Fischer AW, Parlakgul G, Snyder NA, Nguyen TB, Bruns OT, Franke D, Bawendi MG, Lynes MD, Leiria LO, Tseng YH, Inouye KE, Arruda AP, Hotamisligil GS. Brown adipose tissue thermogenic adaptation requires Nrf1-mediated proteasomal activity. Nat Med 2018; 24(3):292-303. PMCID: PMC5839993. PDF
Gao F, McDaniel J, Chen EY, Rockwell HE, Nguyen C, Lynes MD, Tseng YH, Sarangarajan R, Narain NR, Kiebish MA. Adapted MS/MSALL Shotgun Lipidomics Approach for Analysis of Cardiolipin Molecular Species. Lipids. 2018;53(1):133-142. PMID: 29488636. PDF
2017
Ramirez AK, Lynes MD, Shamsi F, Xue R, Tseng YH, Kahn CR, Kasif S, Dreyfuss JM. Integrating extracellular flux measurements and genome-scale modeling reveals novel differences between brown and white adipocytes. Cell Reports 2017;21(11):3040-3048. PDF
Townsend KL, Madden C, Blaszkiewicz M, McDougall L, Tupone D, Lynes MD, Mishina Y, Yu P, Morrison S, Tseng YH. Re-establishment of energy balance in a mouse model with POMC neuron deletion of BMPR1A. Endocrinology 2017;158(12):4233-4245. PMCID: PMC5711385. PDF
Shamsi F, Zhang H, and Tseng YH. MicroRNA regulation of brown adipogenesis and thermogenic energy expenditure. Frontiers in Endocrinology. 2017; 8(205): 1-7. PMCID: PMC5572399. PDF
Shamsi F, Tseng YH. Protocols for generation of immortalized human brown and white preadipocyte cell lines. Methods Mol Biol 2017;1566:77-85. PMCID: PMC5870121. PDF
Hiraike Y, Waki H, Yu J, Nakamura M, Miyake K, Nagano G, Nakaki R, Suzuki K, Kobayashi H, Yamamoto S, Sun W, Aoyama T, Hirota Y, Ohno H, Oki K, Yoneda M, White AP, Tseng YH, Cypess AM, Larsen TJ, Jespersen NJ, Scheele C, Tsutsumi S, Aburatani H, Yamauchi T, and Kadowaki T. NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program. Nat Cell Bio 2017;19(9):1081-1092. PMCID: PMC5885759. PDF
Hou Y, Kitaguchi T, Kriszt R, Tseng YH, Raghunath. Ca2+-associated triphasic pH changes in mitochondria during brown adipocyte activation. Mol Metab 2017; 6(8): 797-808. PMCID: PMC5518710. PDF
Mo Q, Salley J, Roshan T, Baer LA, May FJ, Jaehnig EJ, Lehnig AC, Guo X, Tong Q, Nuotio-Antar AM, Shamsi F, Tseng YH, Stanford KI, Chen MH. Identification and characterization of a supraclavicular brown adipose tissue in mice. JCI Insight 2017;2(11): 93166 . PMCID: PMC5453704. PDF
Lynes M, Leiria L, Lundh M, Bartelt A, Shamsi F, Huang TL, Takahashi H, Hirshman MF, Schlein C, Lee A, Baer LA, May FJ, Gao F, Narain NR, Chen EY, Kiebish MA, Cypess AM, Blüher M, Goodyear LJ, Hotamisligil GS, Stanford KI, Tseng YH. The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue. Nat Med 2017; 23(5): 631-637. PMCID: PMC6484428. PDF
Kriszt R, Arai S, Itoh H, Lee MH, Goralczyk AG, Ang XM, Cypess AM, White AP, Shamsi F, Xue R, Lee JY, Lee SC, Hou Y, Kitaguchi T, Sdhaharan T, Ishiwata S, Lane EB, Chang YT, Tseng YH # , Suzuki M # , Raghunath M # . Optical visualisation of thermogenesis in stimulated single-cell brown adipocytes. Sci Rep 2017; 7(1): 1383. #Corresponding author. PMCID: PMC5431191. PDF
2016
Gao F, McDaniel J, Chen EY, Rockwell H, Lynes MD, Tseng YH, Sarangarajan R, Narain NR and Kiebish MA. Monoacylglycerol analysis using MS/MSALL quadruple time of flight mass spectrometry. Metabolites 2016, 6, 25. PMCID: PMC5041124. PDF
Zhu Y, Gao Y, Tao C, Shao M, Huang W, Yao T, Johnson JA, Liu T, Cypess AM, Gupta O, Holland W, Gupta RK, Spray DC, Tanowitz HB, Cao L, Lynes MD, Tseng YH, Elmquist JK, Williams KW, Lin HV, Scherer PE. Connexin-43 mediates white adipose tissue beiging by facilitating the propagation of sympathetic neuronal signals. Cell Metab 2016; 24: 420–433. PMCID: PMC5024720. PDF
Schulz TJ, Graja A, Huang TL, Xue R, An D, Poehle-Kronawitter S, Lynes MD, Tolkachov A, O’Sullivan LE, Hirshman MF, Schupp M, Goodyear LJ, Mishina Y., Tseng YH. Loss of BMP receptor type 1A in adipose tissue prevents age-related impairment of glucose homeostasis and insulin sensitivity. Diabetologia 2016; 59(8):1769-77. PMCID: PMC4930470. PDF
Jeong HW, Choi RH, McClellan JL, Piroli GG, Frizzell N, Tseng YH, Goodyear LJ, Koh HJ. Tribbles 3 inhibits brown adipocyte differentiation and function by suppressing insulin signaling. Biochem Biophys Res Commun 2016; 2016; 470(4):783-91 PMCID: PMC4768059. PDF
2015
Unsar AM, Mooney B, Hempel N, Corr D, Tseng YH, Xie Y. 3D brown adipogenesis to create “Brown-Fat-in-Microstrands”. Biomaterials 2015; 75:123-134. PMCID: PMC4644497. PDF
Zhang X, Tian Y, Zhang H, Kavishwar A, Lynes MD, Brownell AL, Sun H, Tseng YH, Moore A, Ran C. Curcumin analogues as selective fluorescence imaging probes for brown adipose tissue and monitoring browning. Sci Rep. 2015; DOI: 10.1038/srep13116. PMC4534785. PDF
Zhang H, Guan M, Townsend KL, Huang TL, An D, Yan X, Xue R, Schulz TJ, Winnay J, Mori M, Hirshman MF, Kristiansen K, Tsang JS, White AP, Cypess AM, Goodyear LJ, Tseng YH. MicroRNA-455 regulates brown adipogenesis via a novel HIF1an-AMPK-PGC1α signaling network. EMBO Reports 2015; 16(10):1378-93. PMCID: PMC4766451. PDF
Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, ZhangH, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM, Tseng YH. Clonal analyses and gene profiling identify genetic biomarkers of the thermogenic potential of human brown and white preadipocytes. Nat Med 2015; 21(7):760-768. PMCID: PMC4496292. PDF
Xue R, Lynes MD, Dreyfuss JM, Shamsi F, Schulz TJ, Zhang H, Huang TL, Townsend KL, Li Y, Takahashi H, Weiner LS, White AP, Lynes MS, Rubin LL, Goodyear LJ, Cypess AM Tseng YH. Functional and Clonal Analyses of Human Brown and White Fat Progenitors Identify Markers that Predict Thermogenic Capacity of Mature Adipocytes. Nat Med 2015; 21(7):760-768. PMCID: PMC4496292 PDF
Shinoda K, Luijten IH, Hasegawa Y, Hong H, Sonne SB, Kim M, Xue R, Chondronikola M, Cypess AM, Tseng YH, Nedergaard J, Sidossis LS, Kajimura S. Genetic and functional characterization of clonally derived adult human brown adipocytes. Nat Med. 2015; 21(4):389-94. PMCID:PMC4427356 PDF
Lynes MD, Schulz TJ, Pan AJ, Tseng YH. Disruption of insulin signaling in Myf5-expressing progenitors leads to marked paucity of brown fat, but normal muscle development. Endocrinology 2015; epub ahead of print. PMCID: PMC4398768. PDF
Stanford KI, Middelbeek RJ, Townsend KL, Lee MY, Takahashi H, So K, Hitchcox KM, Markan KR, Hellbach K, Hirshman MF, Tseng YH, Goodyear LJ. A Novel Role for Subcutaneous Adipose Tissue in Exercise-Induced Improvements in Glucose Homeostasis. Diabetes 2015; epub ahead of print. PMCID: PMC4439563 PDF
2014
Lau AM, Tseng YH, Schulz TJ. Adipogenic fate commitment of muscle-derived progenitor cells: isolation, culture, and differentiation. Methods in Molecular Biology 2014; 1213:229-43. PMID: 25173387 PDF
Lynes MD, Tseng YH. Unwiring the transcriptional heat circuit. Proceedings of the National Academy of Sciences 2014; 111(40):14318-9. PMCID: PMC4209983 PDF
Huang P, Schulz TJ, Beauvais A, Tseng YH, Gussoni E. Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signaling. Nat Comm 2014; 5;5:4063. PMCID: PMC4084855 PDF
Kong X, Banks A, Liu T, Kazak L, Rao RR, Cohen P, Wang X, Yu S, Lo JC, Tseng YH, Cypess AM, Xue R, Kleiner S, Kang S, Spiegelman BM, Rosen ED. IRF4 is a key thermogenic transcriptional partner of PGC-1α. Cell 2014; 158(1):69-83. PMCID: PMC4116691 PDF
Ussar S, Dankel S, Boucher J, Lee K, Haering MF, Kleinridders A, Xue R, Macotela Y, Cypess AM, Tseng YH, Mellgren G, Kahn CR. ASC-1, PAT2, and P2RX5 are cell surface markers for white, beige, and brown adipocytes. Sci Transl Med 2014; 6, 247ra103. PMCID: PMC4356008 PDF
Castiglioni A, Hettmer S, Lynes MD, Rao TN, Tchessalova D, Sinha I, Lee BT, Tseng YH, Wagers AJ. Isolation of progenitors that exhibit myogenic/osteogenic bipotency in vitro by fluorescence-activated cell sorting from human fetal muscle. Stem Cell Reports 2014; 2(1)92-106. PMCID: PMC3966115. PDF
Lee JH, Bhang DH, Beede A, Huang TL, Stripp BR, Bloch KD, Wagers AJ, Tseng YH, Ryeom S, Kim CF. Lung stem cell differentiation in mice directed by endothelial cells via a BMP4-NFATc1-thrombospondin-1 axis. Cell 2014; 156(3):440-55. PMCID: PMC3951122 PDF
Mwangi SM, Nezami BG, Obukwelu B, Anitha M, Marri S, Fu P, Epperson MF, Le NA, Shanmugam M, Sitaraman SV, Tseng YH, Anania FA, Srinivasan S. Glial cell line-derived neurotrophic factor protects against high fat diet-induced obesity. Am J Physiol Gastrointest Liver Physiol 2014; 306(6):G515-25. PMCID: PMC3949027 PDF
Townsend KT, Tseng YH. Brown fat fuel utilization and thermogenesis. Trends Endocrinol Metab 2014; 25(4):168-177. PMCID: PMC3972344 (** This article was selected as the 10 best article published in TEM in 2014) PDF
2013
Cypess AM, Doyle AN, Sass CA, Huang TL, Mowschenson PM, Rosen HN, Tseng YH, Palmer EL III, Kolodny GM. Quantification of human and rodent brown adipose tissue function using 99mTc-methoxyisobutylisonitrile SPECT/CT and 18F-FDG PET/CT. J Nuc Med 2013; 19(5):635-9. PMCID: PMC4012367 PDF
Schulz TJ, Tseng YH. Systemic control of brown fat thermogenesis: integration of peripheral and central signals. Ann. N.Y. Acad. Sci 2013; 1302(1):35-41. PMCID: PMC3805713 PDF
Townsend KL, An D, Lynes MD, Huang TL, Zhang, H, Goodyear LJ, Tseng YH. Increased mitochondrial activity in BMP7-treated brown adipocytes, due to increased CPT1- and CD36-mediated fatty acid uptake. Antiox Redox Signal 2013; 19(3):243-257. PMCID: PMC3691916 PDF
Schulz TJ, Tseng YH. Brown adipose tissue: development, metabolism and beyond. Biochem J 2013; 453(2):167-78. PMCID: PMC3887508 PDF
Cypess AM, White AP, Vernochet C, Schulz TJ, Xue R, Sass CA, Huang TL, Roberts-Toler C, Weiner LS, Sze C, Chacko AT, Deschamps LN, Herder LM, Truchan N, Glasgow AL, Holman AR, Gavrila A, Hasselgren PO, Mori MA, Molla M, Tseng YH. Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat. Nat Med 2013; 19(5):635-9. PMCID: PMC3650129 PDF
Ziogas DC, Gras-Miralles B, Mustafa S, Geiger BM, Najarian RM, Nagel JM, Flier SN, Popov Y, Tseng YH, Kokkotou E. Anti-melanin-concentrating hormone treatment attenuates chronic experimental colitis and fibrosis. Am J Physiol Gastrointest Liver Physiol 2013; 304(10):G876-84. PMCID: PMC3652072. PDF
Schulz TJ, Huang P, Huang TL, Xue R, McDougall LE, Townsend KL, Cypess AM, Mishina Y, Gussoni E, Tseng YH. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature 2013; 495(7441):379-83. PMCID: PMC3623555 PDF
Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, Tseng YH, Hellerstein MK, Farmer SR, Goodyear L, Doria A, Blüher M, Hsu SI, Kulkarni RN. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med 2013; 19(2):217-26. PMCID: PMC3567215 PDF
Müller TD, Lee SJ, Jastroch M, Kabra D, Stemmer K, Aichler M, Abplanalp B, Ananthakrishnan G, Bhardwaj N, Collins S, Divanovic S, Endele M, Finan B, Gao Y, Habegger KM, Hembree J, Heppner K, Hofmann S, Holland J, Kutschke M, Krishna R, Lehti M, Oelkrug R, Ottaway N, Perez-Tilve D, Raver C, Walch AK, Schriever S, Schroeder T, Speakman J, Tseng YH, Diaz-Meco M, Pfluger PT, Moscat J, Tschöp MH. p62 links beta-adrenergic input with mitochondrial function. J Clin Invest 2013; 123(1):469-78. PMCID: PMC3533288 PDF
Stanford KI, Middelbeek RJW, Townsend K, Nygaard EB, An D, Hitchcox KM, Markan KR, Nakano K, Jung DY, Lee Y, Kim JK, Hirshman MF, Tseng YH, Goodyear LJ. Brown adipose tissue regulates glucose homeostasis and insulin sensitivity. J Clin Invest 2013; 123(1):215-23. PMCID: PMC3533266 PDF
2012
Macotela Y, Emanuelli B, Mori M, Gesta S, Schulz TJ, Tseng YH, Kahn CR. Intrinsic differences in adipocyte precursor cells from different white fat depots. Diabetes 2012; 61(7):1691-9. PMCID: PMC3379665 PDF
Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, He TC, Kokkotou E, Tseng YH. BMP-7 reverses obesity and regulates appetite through a central mTOR pathway. FASEB J 2012; 26(5):2187-96. PMCID: PMC3336788. PDF
Fujiwaraa K, Hasegawaa K, Ohkumoa T, Miyoshib H, Tseng YH, Yoshikawa K. Necdin controls proliferation of white adipocyte progenitor cells. PLoS One 2012; 7(1):e30948. PMCID: PMC3264651 PDF
Townsend KT, Tseng YH. Brown adipose tissue: recent insights into development, metabolic function, and therapeutic potential. Adipocyte 2012; 1(1):13-24. PMCID: PMC3661118 PDF
2011
Cypess AM, Zhang H, Schulz TJ, Huang TL, Espinoza DO, Kristiansen K, Unterman TG, Tseng YH. Insulin/IGF-I regulation of necdin and brown adipocyte differentiation via CREB- and FoxO1-associated pathways. Endocrinology 2011; 152(10):3680-9. PMCID: PMC3176640. PDF
Schleinitz D, Klöting N, Böttcher Y, Wolf S, Dietrich K, Tönjes A, Breitfeld J, Enigk B, Halbritter J, Körner A, Schön MR, Jenkner J, Tseng YH, Lohmann T, Dreßler M, Stumvoll M, Blüher M, Kovacs P. Genetic and Evolutionary Analyses of the Human Bone Morphogenetic Protein Receptor 2 (BMPR2) in the Pathophysiology of Obesity. PLoS One 2011; 6(2):e16155. PMCID: PMC3032727 PDF
Schulz TJ, Huang TL, Tran TT, Zhang H, Townsend KL, Shadrach J, Cerletti M, McDougall LE, Giorgadze N, Tchkonia T, Schrier D, Falb D, Kirkland JL, Wagers AJ, Tseng YH. Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat. Proc Natl Acad of Sci U S A 2011; 108(1):143-8. PMCID: PMC3017184 PDF
2010
Zhang H, Schulz TJ, Espinoza DO, Huang TL, Emanuelli B, Kristiansen K, Tseng YH. Cross talk between insulin and bone morphogenetic protein signaling systems in brown adipogenesis. Mol Cell Bio 2010; 30(17):4224-33. PMCID: PMC2937545 PDF
Tseng YH, Cypess AM, Kahn CR#. Cellular bioenergetics as a target for obesity therapy. Nat Rev Drug Discov 2010; 9(6):465-81. #Corresponding author. PMCID: PMC2880836 PDF
Boucher J, Tseng YH, Kahn CR. Insulin and insulin-like growth factor-1 receptors act as ligand specific amplitude modulators of a common pathway regulating gene transcription. J Biol Chem 2010; 285(22):17235-45. PMCID: PMC2878077 PDF
2009
Schulz TJ, Tseng YH. Emerging role of bone morphogenetic proteins in adipogenesis and energy metabolism. Cytokine Growth Factor Rev 2009: 20(5-6):523-31. PMCID: PMC2799934 PDF
Cypess AM, Lehman S, Williams G, Tal I, Rodman D, Goldfine AB, Kuo FC, Palmer EL, Tseng YH, Doria A, Kolodny GM, Kahn CR. Identification and importance of brown adipose tissue in adult humans. N Engl J Med 2009; 360(15):1509-17. PMCID: PMC2859951 PDF
Wang WC, Chen HJ, Tseng YH, Lai YC. Identification of somatic mutations in the von Hippel-Lindau (VHL) gene in a patient with renal carcinoma. J Formos Med Assoc 2009; 108(11):886-93. PMID: 19933033. PDF
Böttcher Y, Unbehauen H, Klöting N, Ruschke K, Körner A, Schleinitz D, Tönjes A, Enigk B, Dietrich K, Koriath M, Scholz GH, Tseng YH, Schön MR, Kiess W, Stumvoll M, Blüher M, Kovacs P. Adipose tissue expression and genetic variants of the bone morphogenetic protein receptor 1A gene (BMPR1A) are associated with human obesity. Diabetes 2009; 58(9): 2119-28. PMCID: PMC2731538 PDF
2008
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y, Ahrens MJ, Dudley AT, Norris AW, Kulkarni RN, Kahn CR. New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 2008; 454(7207):1000-4. PMCID: PMC2745972 PDF
Karagiannides I, Torres D, Tseng YH, Bowe C, Carvalho E, Espinoza D, Pothoulakis C, Kokkotou E. Substance P as a novel anti-obesity target. Gastroenterology 2008; 134(3):747-55. PMCID: PMC2359157 PDF
Krüger M, Kratchmarova I, Blagoev B, Tseng YH, Kahn CR, Mann M. Dissection of the insulin signaling pathway via quantitative phosphoproteomics and knockout mouse model. Proc Natl Acad Sci U S A 2008; 105(7):2451-6. PMCID: PMC2268157 PDF
2007
Tseng YH, He T-C. Bone morphogenetic proteins and adipocyte differentiation. Cell Science Reviews 2007; 3(3):342-60. #Corresponding author. PMCID: PMC3336788. PDF
Gesta S**, Tseng YH**, Kahn CR. Developmental origin of fat: tracking obesity to its source. Cell 2007; 131(2):242-56. **Equal authorship. PMID: 17956727. PDF
Chang L, Zhang J, Tseng YH, Xie CQ, Ilany J, Bruning J, Sun Z, Zhu X, Cui T, Youker KA, Yang Q, Kahn CR, Chen YE. Rad GTPase deficiency leads to cardiac hypertrophy. Circulation 2007; 116(25):2976-83. PMID: 18056528 PDF
Mouche S, Mkaddem SB, Wang W, Katic M, Tseng YH, Carnesecchi S, Steger K, Foti M, Meier CA, Muzzin P, Kahn CR, Ogier-Denis E, Szanto I. The NADPH oxidase NOX4 is a key mediator of adipocyte differentiation. Biochim Biophysica Acta 2007; 1773(7):1015-27. PMID: 17553579. PDF
2005
Gunton JE, Kulkarni RN, Yim S, Okada T, Hawthorne WJ, Tseng YH, Roberson RS, Ricordi C, O’Connell PJ, Gonzalez FJ, Kahn CR. Loss of ARNT/H1F1 beta mediates altered gene expression and pancreatic islet dysfunction in human type 2 diabetes. Cell 2005; 122(3):337-49. PMID: 16096055. PDF
Tseng YH, Butte AJ, Kokkotou E, Yechoor VK, Taniguchi CM, Kriauciunas KM, Cypess AL, Niinobe M, Yoshikawa K, Patti ME, Kahn CR. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. Nat Cell Biol 2005; 7(6):601-11. PMID: 15895078. PDF
Fu M, Zhang J, Tseng YH, Cui T, Zhu X, Xiao Y, Mou Y, Leon HD, Chang M, Hamamori Y, Kahn CR, Chen YE. Rad GTPase attenuates vascular lesion formation by inhibition of vascular smooth muscle cell migration. Circulation 2005; 111(8):1071-77. PMID: 15710763. PDF
yhtsenglab.org 